C-H activation
Inert bond functionalization
C-H activation is a type of chemical reaction in which a carbon-hydrogen bond—one of the most stable and ubiquitous bonds in organic molecules—is broken and replaced with a carbon-metal or carbon-other-element bond.
This process is significant in chemistry because C-H bonds are normally unreactive, making selective transformation of specific hydrogens a major challenge.
Researchers used C-H activation to streamline the synthesis of the drug candidate.
The technique enables more efficient routes to complex molecules by avoiding lengthy protection and deprotection steps.
- palladiumElement forty-six, catalytic metal
- oxidative additionMetal cleaves and binds substrate
- organometallicCarbon bonded to metal
- alkaneSaturated hydrocarbon series
- concertedJointly arranged or carried out
methane · iridium · mass spectrometry · rhodium · ligand · ruthenium · inert · catalyst · bond · radical · cleavage · oxidative · substrate · insertion · platinum · mechanism · selectivity · metal
- Organometallic Reactionstransmetalation, oxidative addition
- Named ReactionsDiels-Alder reaction, Claisen condensation, Negishi coupling, Sonogashira coupling, Sandmeyer reaction
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