Claisen condensation
Beta-ketoester formation reaction
Claisen condensation is a reaction in organic chemistry where two ester molecules combine in the presence of a strong base to form a β-keto ester.
The reaction creates a new carbon-carbon bond, making it fundamental for building complex molecules.
Named after German chemist Rainer Ludwig Claisen.
The synthesis relied on a Claisen condensation to construct the carbon backbone.
- esterificationForming esters chemically
- nucleophileElectron-pair donating species
- synthesisCombining parts into whole
- ketoneCarbonyl between two carbons
- transformationThorough change in form
organic chemistry · cyclization · workup · reflux · organic · flask · laboratory · acetylation · sodium · arrows · aldehyde · stirring · acidify · electrons · hydrolysis · base · intermediate · methylene
- chemical reactionscombustion, oxidation, hydrolysis, oxidation-reduction, esterification
- Condensation Reactionsesterification
- Named ReactionsDiels-Alder reaction, Negishi coupling, Sonogashira coupling, Sandmeyer reaction
- carbonylsacetaldehyde, formaldehyde, benzaldehyde, acetone, camphor
condense, condensed, condensation, condensing, condenser, uncondensed, condensible