promethazine

Anti-nausea prescription medication

Promethazine is a prescription antihistamine used to treat allergies, motion sickness, and nausea.

It also has sedative properties, making it useful for calming patients before surgery or helping with sleep.

In recreational contexts, promethazine combined with codeine cough syrup—often mixed with soda and called "lean" or "purple drank"—has become associated with hip-hop culture and carries serious risks of addiction and overdose.

sedative

drowsiness

State of near-sleep

tranquilization · calmness · relaxation · preoperative · hypnotic · lethargy · anxiolytic · pre-surgical · night sweats · insomnia

antihistamine

histamine

Allergy-response compound

rhinitis · urticaria · hives · pruritus · itching · sneezing · runny nose · watery eyes · congestion · angioedema

antiemetic

nausea

Pre-vomiting stomach discomfort

vertigo · dizziness · morning sickness · stomach upset · queasiness · vestibular · travel sickness · car sickness · airsickness

combination

codeine

Opium-derived painkiller

lean · purple drank · sizzurp · opioid · analgesic · pain relief · controlled

formulation

syrup

Thick sugar liquid

intramuscular · intravenous · elixir · rectal · topical · compounded · generic · brand name · dosage · prescription

Categories
Opposites
pharmacological effect on CNS

promethazineamphetamine

Central nervous system stimulant

methamphetamine · caffeine · cocaine · Adderall · dextroamphetamine

antihistamine generation

promethazinecetirizine

Second-generation antihistamine drug

loratadine · Zyrtec · Claritin · Allegra

effect on nausea

promethazineipecac

Substance inducing vomiting

syrup of ipecac · emetic

Family

chlorpromazine, diphenhydramine

Familiarity
Top 1,000,000
Profile
Used worldwide · Timeless · Concrete · Rated PG