biodistribution
Where drugs go
Biodistribution is how a substance spreads through a living organism after administration.
The term appears primarily in pharmacology and medical research, describing where a drug, vaccine, or radioactive tracer travels and accumulates in the body: Biodistribution studies showed the compound concentrated in the liver and kidneys.
Understanding biodistribution helps researchers assess both effectiveness and potential toxicity.
Period for fifty-percent reduction
- clearancePermitted passage or approval
- bioavailabilityFraction reaching active circulation
- first-pass effectDrug breakdown before systemic circulation
- steady stateUnchanging system condition
elimination · biotransformation · absorption · uptake · metabolism · excretion · retention
Relating to liver
lymphatic · tumor · blood-brain barrier · off-target · systemic · localized · vascular · adipose
Nuclear medicine imaging
- SPECTGamma-emitting radiotracer imaging method
- bioluminescenceOrganism-generated light emission
- radiolabelingAttaching radioactive tracers to molecules
- isotopeElemental variant by mass
Bilayer sphere for delivery
- micelleSurfactant molecular cluster
- drug deliveryConveying medicine to tissues
- targeted deliverySending to specific destination
- encapsulationSurrounding on all sides
Scattering across space
- translocationMovement to another place
- circulationMovement through a system
- penetrationEntry into something
- permeationProcess of spreading throughout
migration · localization · sequestration · retention · washout · equilibration · diffusion · partitioning
half-life
Period for fifty-percent reduction
- clearancePermitted passage or approval
- bioavailabilityFraction reaching active circulation
- first-pass effectDrug breakdown before systemic circulation
steady state · elimination · biotransformation · absorption · uptake · metabolism · excretion · retention
hepatic
Relating to liver
cardiac · lymphatic · tumor · blood-brain barrier · off-target · systemic · localized · vascular · adipose · muscle
PET
Nuclear medicine imaging
- SPECTGamma-emitting radiotracer imaging method
- bioluminescenceOrganism-generated light emission
- radiolabelingAttaching radioactive tracers to molecules
liposome
Bilayer sphere for delivery
- micelleSurfactant molecular cluster
- drug deliveryConveying medicine to tissues
- targeted deliverySending to specific destination
encapsulation · payload · accumulation · clearance · phagocytosis
dispersion
Scattering across space
- translocationMovement to another place
- circulationMovement through a system
- penetrationEntry into something
permeation · migration · localization · sequestration · retention · washout · equilibration · diffusion · partitioning · trafficking
distribute, distribution, distributor, distributors, redistribute, redistribution, distributive, undistributed