mevalonate pathway
Sterol synthesis route
The mevalonate pathway is a metabolic sequence in cells that produces cholesterol, steroid hormones, and other essential molecules.
It begins with acetyl-CoA and proceeds through mevalonate as a key intermediate.
Statin drugs work by inhibiting an enzyme in this pathway, reducing cholesterol synthesis.
Also called the HMG-CoA reductase pathway.
- cholesterolWaxy lipid in blood
- statinsLipid-lowering pharmaceuticals
- terpenesHydrocarbon plant compounds
- acetyl-CoAActivated two-carbon metabolic intermediate
- lipidsWater-insoluble biomolecules
sterols · synthesis · squalene · lovastatin · biosynthesis · cytosol · liver · enzyme · regulation · feedback · metabolism · steroid
- Biosynthesisprotein synthesis, DNA synthesis, fatty acid synthesis, lipogenesis, hemoglobin synthesis
- lipid metabolismlipids, lipogenesis, fats, triglycerides, fat metabolism
- terpeneslimonene, camphor, isoprene, terpenes, squalene