cyclisation

Forming molecular rings

Cyclisation is the British spelling of cyclization—a chemical reaction in which a chain of atoms forms a ring, creating a cyclic compound.

The process is fundamental in organic chemistry and biochemistry, appearing in the synthesis of sugars, steroids, and countless pharmaceuticals: The cyclisation of squalene produces cholesterol.

rings

benzene

Aromatic hydrocarbon solvent

  • lactoneCyclic ester from self-reaction
  • furanAromatic oxygen-containing ring
  • pyridineBasic six-membered nitrogen heterocycle

cyclohexane · cyclopentane · cyclopropane · dioxane · aromatic · annular · toroid · epoxide

mechanism

intramolecular

Within a single molecule

elimination · addition · rearrangement · tautomerism · stereochemistry · chirality · isomerization · concerted · stepwise · radical

synthesis

catalyst

Agent enabling change

  • enzymeProtein that hastens reactions
  • reagentSubstance prompting chemical change
  • substrateUnderlying supporting material

product · yield · selectivity · biosynthesis · polymerization · metathesis · Diels-Alder · Friedel-Crafts · Bergman · click

Opposites
molecular topology transformation

cyclisationring-opening

Cleaving a cyclic structure

linearization · polymerization

chain topology

cyclisationpolymerisation

Forming long molecular chains

Family

cycle, bicycle, tricycle, motorcycle, cycling, cyclic, encyclopedia, cyclical, cyclist

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