nonsense mutation
Codon becomes terminator
A nonsense mutation is a genetic change that converts a normal codon into a stop signal, prematurely halting protein synthesis.
The resulting protein is truncated and usually nonfunctional.
The term contrasts with missense mutations, which substitute one amino acid for another, and silent mutations, which have no effect on the protein.
pathology
Abnormality in inherited code
- hereditary diseaseCondition inherited from parents
- haploinsufficiencyLone working allele inadequate
- cystic fibrosisGenetic disorder thickening mucus
- hemophiliaGenetic clotting impairment
detection
Testing DNA for abnormalities
- sequencingDetermining element order
- prenatal diagnosisMedical assessment of fetus
- pathogenicityAbility to cause illness
- genetic counselingGuidance on inherited conditions
genetic disorder
Abnormality in inherited code
- hereditary diseaseCondition inherited from parents
- haploinsufficiencyLone working allele inadequate
- cystic fibrosisGenetic disorder thickening mucus
readthrough
Complete script recitation
- reading frameTriplet-grouping starting point
genetic screening
Testing DNA for abnormalities
- sequencingDetermining element order
- prenatal diagnosisMedical assessment of fetus
- pathogenicityAbility to cause illness
- Genetic Variationsinsertion, inversion, translocation, deletion, allele
- Cell ErrorsDNA damage, frameshift, translocation, inversion, transcription error
- mutationsmutant, deletion, insertion, frameshift, substitution
- translationtranslator, literal translation, literary translation, free translation, French translation
- reading framesopen reading frame, frameshift, codon, triplet
nonsense, mutation, mutate, nonsensical, transmutation, nonsenses, mutating, mutates, mutations