leptin
Fat cell signal
Leptin is a hormone produced by fat cells that signals the brain to regulate appetite and energy expenditure.
When fat stores increase, leptin levels rise, suppressing hunger; when stores drop, leptin falls, triggering appetite.
The hormone plays a central role in metabolism and body weight regulation: Leptin resistance may contribute to obesity.
Intake versus expenditure ratio
- thermogenesisMetabolic production of warmth
- insulin sensitivityCells' glucose uptake ability
- fat cellsLipid-storing body units
- body weightPhysical mass of person
obesity · energy expenditure · caloric intake · body composition · metabolic rate · BMI · adiposity · brown fat
Appetite-stimulating stomach peptide
- insulinPancreatic glucose-regulating hormone
- peptideShort amino acid chain
- receptorSignal-receiving molecule
- hypothalamusSubthalamic regulatory brain region
signaling · secretion · endocrine · pituitary · neuroendocrine · feedback · regulation · cortisol
State of being complete
- appetite controlManaging desire to eat
- satiationState of complete fulfillment
- repletionState of being overfull
- anti-hungerOpposing food deprivation
Incapacitating final blow
- recombinantGenetically engineered combination
- clinical trialsControlled health research experiments
- biomarkerMeasurable biological health signal
- assayCompositional evaluation procedure
Friedman · discovery · gene therapy · pharmaceutical · mutation · replacement therapy · metabolic syndrome
energy balance
Intake versus expenditure ratio
- thermogenesisMetabolic production of warmth
- insulin sensitivityCells' glucose uptake ability
- fat cellsLipid-storing body units
body weight · obesity · energy expenditure · caloric intake · body composition · metabolic rate · BMI · adiposity · brown fat
ghrelin
Appetite-stimulating stomach peptide
- insulinPancreatic glucose-regulating hormone
- peptideShort amino acid chain
- receptorSignal-receiving molecule
hypothalamus · signaling · secretion · endocrine · pituitary · neuroendocrine · feedback · regulation · cortisol · thyroid
fullness
State of being complete
- appetite controlManaging desire to eat
- satiationState of complete fulfillment
- repletionState of being overfull
knockout
Incapacitating final blow
- recombinantGenetically engineered combination
- clinical trialsControlled health research experiments
- biomarkerMeasurable biological health signal
assay · Friedman · discovery · gene therapy · pharmaceutical · mutation · replacement therapy · metabolic syndrome