Williamson synthesis

Alkoxide attacks halide

The Williamson synthesis is a chemical reaction for making ethers by combining an alkoxide ion with an alkyl halide.

Named for English chemist Alexander Williamson, who developed it in the 1850s, it remains a standard method in organic chemistry for producing both simple and complex ethers: The students performed a Williamson synthesis to prepare diethyl ether.

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SN2 · epoxide · organic · reaction · laboratory · flask · reflux · alcohol · benzyl · phenol · nucleophile · mechanism · yield · solvent · base · methyl · ethyl · bond

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