Williamson synthesis
Alkoxide attacks halide
The Williamson synthesis is a chemical reaction for making ethers by combining an alkoxide ion with an alkyl halide.
Named for English chemist Alexander Williamson, who developed it in the 1850s, it remains a standard method in organic chemistry for producing both simple and complex ethers: The students performed a Williamson synthesis to prepare diethyl ether.
- etherVolatile organic solvent
- halideHalogen-element compound
- sodiumEleventh element, highly reactive
- potassiumNineteenth element, symbol K
- substitutionExchange of one for another
SN2 · epoxide · organic · reaction · laboratory · flask · reflux · alcohol · benzyl · phenol · nucleophile · mechanism · yield · solvent · base · methyl · ethyl · bond
- Substitution ReactionsSN1, SN2, SN2 reaction, Friedel-Crafts, nitration
- alkylationmethylation