worn to the bone

Related

haggard · ragged · threadbare · frayed · skeletal · gaunt · hollow · depleted · run-down · beaten · grinding · tireless · overworked · sleepless · aching · brittle · thin · weathered

Opposites
energy and vitality

worn to the bonefull of energy

energized · invigorated · revitalized · refreshed · vibrant

physical condition

worn to the bonewell-rested

Having slept enough

rested · fit as a fiddle · hale and hearty · recuperated · restored

freshness/newness

worn to the bonefresh

Newly made, not stale

brand new · untouched · unspoiled · pristine · green

Familiarity
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