deep anguish

• tormentSevere prolonged suffering
• agonyExtreme physical or emotional pain
• despairTotal absence of hope
• griefIntense sorrow from loss
• heartbreakCrushing emotional pain

suffering · sorrow · anguished · wailing · tears · devastation · hollowness · sobbing · writhing · inconsolable · raw · piercing · gut-wrenching · howling · loss · mourning · darkness · unbearable